Low-Grade Inflammation, Obesity, and Insulin Resistance in Adolescents

Obesity-Induced Inflammation and Insulin Resistance

Immune response and metabolic regulation are highly integrated and this interface maintains a central homeostatic system, dysfunction of which can cause obesity-associated metabolic disorder such as type 2 diabetes, fatty liver disease, and cardiovascular disease. Insulin resistance is an underlying basis for the pathogenesis of these metabolic diseases. Overnutrition or obesity activates the i...

Maternal obesity increases insulin resistance, low-grade inflammation and osteochondrosis lesions in foals and yearlings until 18 months of age

INTRODUCTION Obesity is a growing concern in horses. The effects of maternal obesity on maternal metabolism and low-grade inflammation during pregnancy, as well as offspring growth, metabolism, low-grade inflammation, testicular maturation and osteochondrotic lesions until 18 months of age were investigated. MATERIAL AND METHODS Twenty-four mares were used and separated into two groups at ins...

Low grade chronic inflammation in the RISC population: associations with insulin resistance and cardiometabolic risk profile

1 Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, the Netherlands 2 Department of Clinical Sciences, Lund University, University Hospital, Malmö, Sweden 3 Metabolic Research Unit, St James’ Hospital, Trinity College, Dublin 8, Ireland 4 Unidad de Investigacion, Hospital Universitario La Paz, Madrid, Spain 5 Division of Therapeutical Teaching for Chronic D...

Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes.

Vascular dysfunction, low-grade inflammation, insulin resistance, and impaired fibrinolysis have each been reported to be present in type 2 diabetes, but their relationships, and the role of obesity, have not been investigated. We measured insulin sensitivity (euglycemic clamp), forearm blood flow responses to graded local acetylcholine (Ach) and sodium nitroprusside (SNP) infusions, plasma con...

Chronic Low-grade Inflammation after Exercise: Controversies